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4-Aco-DMT Overview[edit]

What it is

4-AcO-DMT is a synthetic tryptamine psychedelic.

Chemically, it’s an acetylated analog of psilocin (the active compound in psilocybin mushrooms).

In the body, it’s widely believed to convert to psilocin, which explains its mushroom-like effects.

Subjective effects

Commonly reported effects resemble psilocybin mushrooms, including:

Altered perception and visual patterns

Changes in thought, mood, and sense of self

Emotional amplification and introspection

Some users describe it as smoother or more “neutral” than mushrooms, with less nausea, though experiences vary.

Duration

Typically moderate in length compared to other psychedelics:

Onset: relatively quick

Peak: a few hours

Total experience: often similar to mushrooms rather than LSD

Pharmacology

Acts primarily on serotonin (5-HT2A) receptors, like classic psychedelics.

Considered a prodrug to psilocin (meaning the body converts it into the active form).

Risks & safety considerations

Psychological risks include anxiety, panic, confusion, or triggering latent mental health conditions.

Can impair judgment and perception during the experience.

Limited formal research compared to older psychedelics; long-term effects are not well studied.

Mixing with certain medications (especially MAOIs or SSRIs) may alter effects or risks.

Legal status

Varies by country and region.

In some places it is explicitly illegal; in others it exists in a legal gray area but may still be treated as an analogue of controlled substances.

Research & cultural context

Interest in 4-AcO-DMT largely comes from psychedelic research communities and discussions around therapeutic potential of psilocybin-like compounds.

It is not an approved medication and remains primarily a research chemical.

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